Predictive values of serum matrix metalloproteinase-9 and ferritin for hemorrhagic transformation after acute ischemic stroke / 国际脑血管病杂志

ABSTRACT

Objective To investigate the predictive values of matrix metalloproteinase-9 (MMP-9) and serum ferritin (SF) for hemorrhagic transformation (HT) after acute ischemic stroke.Methods The patients with fist-ever acute ischemic stroke within 24 h of onset were selected.The demographic and clinical data were collected.The MMP-9 and SF levels were detected.The demographic and clinical data and laboratory results were compared between a HT group and a non-HT group.Multivariable logistic regression analysis was used to determine the independent risk factor for HT.The receiver operating characteristic (ROC) curve was used to identify the predictive values of MMP-9 and SF for HT.Results A total of 150 patients were enrolled,their mean age was 67.01 ± 9.11 years,including 65 males (43.33％).There were 32 patients (21.33％) in the HT group and 118 (78.67％) in the non-HT group.Univariate analysis showed that MMP-9 (161.19 ±36.86 μg/L vs.100.18 ±36.70 μg/L;t =8.333,P＜0.001) and SF (195.50 [188.25-201.00] μg/L vs.175.00[165.00-189.25] μg/L;Z =4.891,P ＜0.001) in the HT group were significantly higher than those in the non-HT group.Multivariable logistic regression analysis showed that diabetes (odds ratio [OR] 2.273,95％ confidence interval [CI] 1.019-5.070;P =0.047),atrial fibrillation (OR 4.846,95％ CI 1.934-12.146;P=0.001),MMP-9 (OR 3.176,95％ CI 1.842-5.479;P＜ 0.001),hypersensitivity C reactive protein (OR 2.243,95％ CI 1.015-4.954;P =0.045),and SF (OR 2.722,95％ CI 1.586-4.672;P ＜ 0.001) were the independent risk factors for HT.The ROC curve analysis showed that MMP-9 (area under curve 0.904,95％ CI 0.851-0.957) and SF (area under curve 0.776,95％ CI 0.684-0.869) had significant predictive values for HT.When the cut-off value of MMP-9 was 133 μg/L,the sensitivity and specificity were 84.4％ and 15.3％,respectively.When the cut-off value of SF was 187.5 μg/L,the sensitivity and specificity were 78.1％ and 27.1％,respectively.Conclusions The MMP-9 and SF levels were significantly increased in acute ischemic stroke patients with HT.Early detection of serum MMP-9 and SF levels help to predict the risk of HT.