Correlation between C3435T polymorphism of ABCB1 gene and response to antiplatelet drugs in Chinese Han patients with ischemic stroke / 国际脑血管病杂志

ABSTRACT

Objective To investigate the correlation between multidrug resistance gene ABCB1 C3435T polymorphism and antiplatelet drug reactivity in Chinese Han patients with ischemic stroke.Methods Consecutive inpatients with non-cardiogenic embolic ischemic stroke were enrolled.They were divided into a good response to antiplatelet drug group and poor response to antiplatelet drug group according to the results of thrombelastogram.Polymerase chain reaction-restriction fragment length polymorphism technique was use to detect the C3435T polymorphism of ABCB1 gene.Multivariate logistic regression analysis was used to determine the independent risk factors for poor response to antiplatelet drugs in patients with ischemic stroke.Results A total of 260 patients with ischemic stroke were enrolled,including 87 females (33.5％) and 173 males (66.5％).There were 193 patients (74.2％) in the good response group and 67 (25.8％)in the poor response group.The age was younger and male was more common in the good response group,and the proportions of smoking and triacylglycerol level were significantly higher (all P ＜0.05).The frequencies of TT genotype and T allele of the poor response group were significantly higher than those of the good response group (all P ＜ 0.05).Multivariable logistic regression analysis showed that triacylglycerol (odds ratio 1.045,95％ confidence interval 1.011-2.010;P =0.014) and C3435T TT genotype (odds ratio 1.512,95％ confidence interval 1.013-2.256;P=0.043) were the independent risk factors for poor response to antiplatelet drugs after adjusting confounding factors.Conclusion The C3435T TT genotype is an independent risk factor for poor response to antiplatelet drugs in Chinese Han patients with ischemic stroke.