Research status and application prospects of Ajuba in cancer / 国际生物医学工程杂志

ABSTRACT

Ajuba was found in cell connections, and the subsequent studies showed that it can shuttle between the nucleus and cytoplasm for signals transmission. Under normal physiological conditions, Ajuba promotes cell proliferation and differentiation by regulating cell cycle and participating in signaling pathways. In addition, Ajuba is closely related to the development of various tumors, such as breast cancer, colorectal cancer, head and neck squamous cell carcinoma, etc. However, Ajuba functions as an oncogene or a tumor suppressor gene in different tumors. In carcinomas, Ajuba can also promote tumor cell proliferation and promote tumor invasion and metastasis by regulating epithelial-mesenchymal transition. Some progress has been made in the development of small molecular inhibitors or targeted drugs for Ajuba, and there are considerable therapeutic prospects.