Evaluation of anticoagulant therapy after cerebral hemorrhage combined with deep vein thrombosis of lower extremity / 国际外科学杂志

ABSTRACT

Objective To evaluate the efficacy and safety of anticoagulant therapy with low-molecularweight heparin after cerebral hemorrhage combined with deep vein thrombosis of lower extremity.Methods One hundred and fifty-three cases of deep vein thrombosis of lower extremity after intracerebral hemorrhage were collected of Beijing Tiantan Hospital,Capital Medical University from June 2014 to June 2016.According to whether accepted anticoagulant therapy with low-molecular-weight heparin,the patients were divided into treatment group (n =79) and control group(n =74).Compared the head CT images and the ultrasound of lower extremity venous in the day when admissed to hospital and in the 7th day after treatment.The measurement data was adopted by t test,Chi-square test was adopted in the count data.Results Before the low-molecular-weight heparin therapy,the average bleeding volume in intracerebral was (1.38 ± 0.45) ml for the anticoagulant therapy group.After 7 days of low-molecular-weight heparin therapy,the average bleeding volune in intracerebral was (1.01 ± 0.54) ml,there was no increasing cerebral hemorrhage,with a statistically significant difference (P =0.000).The bleeding volume in intracerebral was(1.47 ± 0.47) ml of control group cases,and after 7 days it became (1.17 ± 0.52) ml,with a statistically significant difference (P =0.000),all these showed that cerebral hemorrhage had significantly absorbed.There was no statistically significant difference between the treatment group and the control group (P =0.123).It explained that anticoagulation was not increased intracranial hemorrhage with low-molecular-weight heparin.ultrasound showed that the lower extremity venous thrombosis was stable or decreased before and after anticoagulant therapy,and the difference was statistically significant (P =0.000),indicating that the anticoagulant therapy was effective.Conclusions It is safe and effective in low-molecular-weight heparin anticoagulant therapy for deep vein thrombosis of lower extremity after intracerebral hemorrhage.But patients need strict screening,and follow the individualized treatment.