Correlation of hydrogen sulfide and homocysteine with deep venous thrombosis of the lower extremities / 国际外科学杂志

ABSTRACT

Objective To analysis the role of hydrogen sulfide in the process of venous thrombosis and the correlation with homocysteine.Methods A retrospective case-control study was carried on deep venous thrombosis patients and healthy population in the People's Hospital of Xinjiang Uygur Automous Region from March 2015 to November 2016,which including 169 patients and 169 health persons.Detected the concentration of hydrogen sulfide and homocysteine in plasma of study population,compared their differences in the two groups by using single-factor analysis,and analysed the correlation of the concentration between hydrogen sulfide and homocysteine.The median and quartile spacing were used to express values with abnormal distribution,and Mann-Whitney U test was performed between groups.Pearson or Spearman correlation coefficient were used to describe the correlation between two variables.Results The Plasma concentrations of hydrogen sulfide in both groups were 29.30 nmol/ml (23.89,37.82),32.99 nmol/ml (26.29,39.68) and the plasma concentrations of homocysteine were 15.37 μmol/L(11.64,19.68),12.13 μmol/L(9.65,15.95),their concen trations in two groups have statistic difference (P ＜ 0.05) and were risk factors for deep venous thrombosis;the plasma concentration of hydrogen sulfide and homocysteine was negatively correlated(P ＜ 0.05).Conclusion The plasma concentration of hydrogen sulfide is associated with deep venous thrombosis and a protective factor for deep venous thrombosis;there is a negative correlation between plasma homocysteine and hydrogen sulfide,they may play an interactional role in the process of thrombosis.