Relationship between the metabolic syndrome and the risk of prostate cancer / 国际外科学杂志

ABSTRACT

Objeetive To evaluate the relationship between the metabolic syndrome and the risk of prostate cancer.Methods The clinical data of 118 patients with primary prostate cancer who were admitted to the Beijing Friendship Hospital,Capital Medical University from February 2013 to September 2017 were retrospectively analyzed.All the patients were divided into metabolic syndrome group (n =50) and non-metabolic syndrome group (n =68) according to the diagnosed standard of metabolic syndrome.The patients' clinical data were expressed as percentage(％) and collected including age between the two groups,body mass index,blood pressure,fasting blood glucose,triglyceride,high density lipoprotein,low density lipoprotein,prostate volume,prostate specific antigen (PSA) value,Gleason score and TNM staging.The data were analysed by the statistical analysis method.Chi-square test was used to compare the enumeration data.Measurement data were expressed as ((x) ± s),and using t test comparison between groups.The relationship between various variable factors and prostate cancer used multivariate logistic regression analysis.Results There was no significantly difference between the two groups including age,blood pressure,triglyceride,low density lipoprotein and Gleason score (P ＞ 0.05).The body mass index,fasting blood glucose and prostate volume in the metabolic syndrome group [(26.62 ± 16.43) kg/m2,(8.1 ± 1.7) mmol/L,(50.1 ± 12.2) ml] are significantly higher than in the non-metabolic syndrome group [(22.16±15.64) kg/m2,(6.3 ±1.5) mmol/L,(40.3 ±14.1) ml] (P＜0.05).The high density lipoprotein and PSA value in the metabolic syndrome group [(0.9 ± 0.4) mmol/L,(21.4 ± 7.9) ng/dl] were significantly lower than in the non-metabolic syndrome group [(1.40 ± 0.64) mmol/L、(36.2 ± 8.2) ng/dl] (P ＜ 0.05).The proportion of high-risk prostate cancer in the metabolic syndrome group (62％,31/50) was significantly higher than that in the non-metabolic syndrome group (33.8％,23/68),P ＜ 0.05.Logistic regression analysis showed that the body mass index and high density lipoprotein hypertension had a positive correlation with high risk of prostate cancer.Conclusions The metabolic syndrome might increase the incidence risk of high risk of prostate cancer.The two components of metabolic syndrome,body mass index and high density lipoprotein,should be paid attention in clinical practice.