Expression of TRIM2 protein in colon cancer tissues and its clinical significance / 国际外科学杂志

ABSTRACT

Objective To study the expression of TRIM2 protein in colon cancer tissues and paracancerous tissues and its relationship between TRIM2 protein expression and clinicopathological parameters and prognosis of patients with colon cancer.Methods Immunohistochemistry was used to detect the expression of TRIM2 protein in colon cancer tissues and paracancerous tissues of 200 colon cancer patients undergoing colon cancer radical surgery from Januany to December 2013 in the First Affiliated Hospital of Air Force Military Medical University.According to the results of TRIM2 protein expression,patients were divided into TRIM2 low expression group (n =114) and TRIM2 high expression group (n =86).The relationship between TRIM2 protein expression and clinicopathological parameters and prognosis in patients with colon cancer were analyzed by chi-square test,Kaplan-Meier method and log-rank test.Results There were 57％ (114/200) patients with low expression of TRIM2 protein in 200 cases of colon cancer,and there was a statistically significant difference compared with the adjacent tissues (P ＜ 0.001).The expression of TRIM2 protein was associated with tumor invasion depth (P =0.010),lymph node metastasis (P =0.019),UICC clinical stage (P ＜ 0.001) and vascular tumor embolus (P =0.025).The 5-year overall survival and disease-free survival of patients with high TRIM2 expression were better than those with low TRIM2 expression [(55.64 ± 0.98) months,x2 =20.982,P ＜ 0.001].Univariate analysis suggested that UICC clinical staging (P =0.013),depth of tumor invasion (P =0.002),and TRIM2 protein expression (P ＜ 0.001) were risk factors for 5-year overall survival and tumor-free survival after radical resection of colon cancer.Multivariate analysis showed that TRIM2 protein expression was an independent risk factor for 5-year overall survival and disease-free survival in patients with colon cancer (HR =0.346,95％ CI0.204 ～ 0.588,P ＜ 0.001;HR =0.330,95％ CI0.195-0.560,P ＜0.001).Conclusion The expression of TRIM2 protein in colon cancer tissues is decreased and associated with tumor progression and poor prognosis.It can be used as a molecular marker for prognosis of postoperative colon cancer patients.