Therapeutic effect of axillary lymph node dissection and local radiotherapy on patients with stage Ⅰ-Ⅱ sentinel lymph node-positive breast cancer / 国际外科学杂志

ABSTRACT

Objective To compare the recurrence rate and survival rate of axillary lymphadenectomy and axillary local radiotherapy after breast-conserving surgery in patients with stage Ⅰ-Ⅱ breast cancer who were positive for sentinel lymph node biopsy.Methods A retrospective analysis of 137 patients with stage Ⅰ-Ⅱ breast cancer who were positive for sentinel lymph node biopsy from January 2010 to July 2015 in Yulin First Hospital was performed.Patients underwent axillary lymph node dissection (ALND) after breast-conserving surgery were assigned to the ALND group (n =92),patients with axillary local radiotherapy (RNI) after breast-conserving surgery were assigned to the RNI group (n =45),and the general clinical characteristics (mean age,menopause,clinical stage,etc.) were compared between the two groups,and prognosis (2-year recurrence rate,distant metastasis rate,cumulative 2-year event-free survival,cumulative 2-year overall survival).Measurement data were expressed as ((x) ± s),and t test was used for comparison between groups;count data was expressed as rate (％),and chi-square test was used for comparison between groups.Results There were no statistical differences in general clinical characteristics (mean age,menopausal number,clinical stage,etc.) between the two groups.For patients with stage Ⅰ-Ⅱ sentinel lymph node-positive adenocarcinoma,breast-conserving surgery plus axillary lymph node dissection (ALND group) and breast-conserving 2-year recurrence rate (4.4％,6.7％,P =0.87)and distant metastasis rate (9.7％,15.6％,P =0.48) and cumulative 2 years of surgery plus axillary local radiotherapy (RNI group) There were no statistically significant differences in event-free survival (85.9％,75.6％,P =0.14) and cumulative 2-year overall survival (90.2％,86.7％,P =0.53).Conclusion For patients with stage Ⅰ-Ⅱ sentinel-positive breast cancer,axillary RNI may be a new treatment for ALND.