A simple method for the(7-methoxy-1-naphthyl)acetonitrile synthesis / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 1141-1144, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-693361
ABSTRACT
Objective To research and optimize the synthesis process of(7-methoxy-1-naphthyl)acetonitrile for industrial production.Methods(7-Methoxy-1-naphthyl)acetonitrile was synthesized from industrial grade 1-amino-7-naphthol,by diazotiza?tion,Sandmeyer reaction and coupled reaction.Factors such as the reaction temperature,the reaction time and the ratio of the raw ma?terial were optimized to make the reaction conditions mild.The total yield was 53.9%.Results and Conclusion The structures of in?termediate and target compounds were confirmed by MS and 1H NMR.The new method is suitable for industrial production.
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Pharmaceutical Research
Year:
2017
Type:
Article
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