Biological function of myeloid-derived suppressor cells and their related inhibitors:research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
; (6): 25-31, 2018.
Article
in Zh
| WPRIM
| ID: wpr-693368
Responsible library:
WPRO
ABSTRACT
Myeloid-derived suppressor cells(MDSC)are heterogeneous cells with the myeloid progenitor cells and the imma-ture myeloid cells accumulated in pathological conditions.MDSC can inhibit the host immune response to tumors via inhibiting the pro-liferation and cytotoxicity of T cells as well as promoting the proliferation of protumorigenic T regulatory cells(Treg).In addition,MD-SC can also promote the angiogenesis and the tumor invasion and metastasis.Therefore,MDSC are potential therapeutic targets for a variety of tumors.This review summarizes the biological function of MDSC along with the MDSC-targeted inhibitors and their applica-tions in cancer immunotherapy.
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Language:
Zh
Journal:
Journal of International Pharmaceutical Research
Year:
2018
Type:
Article