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Clinical observation on the effect of elemene injection maintenance treatment on the recurrence time of malignant pleural effusion / 国际肿瘤学杂志
Journal of International Oncology ; (12): 70-72, 2018.
Article in Chinese | WPRIM | ID: wpr-693446
ABSTRACT
Objective To observe the effect of elemene injection for the maintenance treatment of malignant pleural effusion.Methods A total of 90 patients with malignant pleural effusion from May 2014 to Apirl 2016 in First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were collected.They were divided into observation group (n =45) and control group (n =45) according to the random number table method.The patients of the two groups were treated with pleural effusion drainage through thoracocentesis,and Mannatide (Lifein) and carboplatin were poured.The observation group sequentially received maintenance treatment of elemene injection.The therapeutic effects of the two groups were compared.Results At the 12th month after treatment,the difference of relapse rate between the two groups was statistically significant(82.2% vs.100.0%,x2 =8.780,P =0.003).The median progression-free survival (95% CI) of the observation group and the control group were 10.00 (9.15-10.85) months and 6.00(4.74-7.26) months respectively,with a significant difference (x2 =40.475,P < 0.001).The improvement rates of life quality of the observation group were 82.22%,57.78%,54.55% respectively at one,six,twelve months after perfusion treatment,and the improvement rates of the control group were 84.44%,23.26%,0 respectively.The data differences between the two groups were statistically significant at six,twelve months (x2 =10.840,P =0.001;x2 =32.390,P < 0.001).The one year survival rates of the observation group and the control group were 97.78% and 95.56%,and the difference was statistically significant (P =1.000).Conclusion The effect of elemene injection for the maintenance treatment of malignant pleural effusion is obvious,which can prolong the progression-free survival time and can significantly improve the quality of life.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of International Oncology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of International Oncology Year: 2018 Type: Article