Expressions and clinical significances of CD68 and ABHD5 in gastric carcinoma / 国际肿瘤学杂志

ABSTRACT

Objective To evaluate the expressions of CD68 and alpha/beta hydrolase domain-containing protein 5 (ABHD5) in gastric carcinoma and their interrelation,and the relationship with the clinicopathological features of gastric carcinoma.Methods The immunohistochemistry staining was used to determine the expressions of CD68 and ABHD5 in 60 cases of gastric carcinoma and 30 cases of adjacent normal tissues.The relationships between CD68,ABHD5 and clinicopathological features of gastric carcinoma,and the correlation of them were analyzed.Results The expressions of CD68 and ABHD5 in gastric carcinoma were significantly higher than those in adjacent normal tissues,and the positive expression rates were 65.00％ vs.26.67％(x2 =11.779,P =0.001) and 60.00％ vs.30.00％ (x2 =7.200,P =0.007) respectively,with significant differences.The expression of CD68 was related to TNM stage (x2 =7.959,P =0.005),lymph node metastasis (x2 =6.901,P =0.009) and serosal invasion (x2 =5.833,P =0.016),but it was not associated with pathological grade (x2 =0.028,P =0.866),gender (x2 =0.533,P =0.465) and age (x2 =0.060,P =0.807).The expression of ABHD5 was related to pathological grade (x2 =4.318,P =0.038),TNM stage (/x2 =4.051,P =0.044) and serosal invasion (x2 =5.275,P =0.022),but it was not associated with lymph node metastasis (x2 =0.545,P =0.460),gender (x2 =0.191,P =0.662) and age (x2 =1.358,P =0.244).Contingency correlation analysis showed that there was positive correlation between CD68 and ABHD5 in gastric cancer (c =0.328,P =0.010).Conclusion The expressions of CD68 and ABHD5 in gastric carcinoma are higher than those in adjacent normal tissues,which are correlated with the different clinicopathological features of gastric carcinoma.The expression of CD68 is positively correlated with the expression of ABHD5.The combined detection of CD68 and ABHD5 expressions in gastric carcinoma is helpful to evaluate the invasion,metastasis and prognosis of gastric carcinoma.