Mechanism of microphthalmia family of transcription factors in tumorigenesis / 国际肿瘤学杂志
Journal of International Oncology
; (12): 292-295, 2018.
Article
in Zh
| WPRIM
| ID: wpr-693498
Responsible library:
WPRO
ABSTRACT
Microphthalmia family of transcription factors (MiT/TFE) is very important for the regulation of cancer cell proliferation and energy metabolism.The MiT/TFE promotes the genesis and development of tumors by up-regulating the expression of lysosomal genes as well as acting on the oxidative metabolism and the oxidative stress response.MiT/TFE can also regulate lysosomal signaling including the mTORC1 and Wnt/3-catenin pathways.The relationship between MiT/TFE and folliculin (FLCN) is associated with the tumorigenesis.
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WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2018
Type:
Article