Molecular mechanism in malignant progression of meningioma / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 494-498, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-693541
ABSTRACT
Atypical and malignant meningiomas are characterized by high invasiveness and local recurrence.Traditional treatments such as surgery,radiotherapy and chemotherapy have limited effects.Recently,with the further study of the pathogenesis of meningioma and the development of molecular biology techniques,some new biomarkers have been found to play important roles in development and malignant progression of meningioma.Several genetic and epigenetic factors have been identified as contributing to the malignant progression of meningioma.Genetic factors include multiple phenotypic changes such as abnormal cell proliferation,increased cell invasiveness,angiogenesis,apoptosis inhibition,and changes in telomerase activity.And the discovery of biomarkers provides references for early diagnosis,molecular targeted therapy and prognosis assessment of high-grade meningiomas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Screening study
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2018
Type:
Article
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