Effect of Taohong-Siwu decoction combined with percutaneous vertebroplasty on elderly patients with osteoporotic vertebral compression fractures / 国际中医中药杂志

ABSTRACT

Objective To analyze the effect of Taohong-Siwu decoction combined with percutaneous vertebroplasty on elderly patients with osteoporotic vertebral compression fractures. Methods A total of 60 elderly patients with osteoporotic vertebral compression fractures, from March 2015 to March 2017, were randomly divided into two groups(30 patients in each group). The patients in the control group were treated with percutaneous vertebroplasty, and the patinets in the study group received Taohong-Siwu decoction combined with percutaneous vertebroplasty. Before treatment and at 4 weeks after treatment, the ODI scores, VAS scores were recorded, and the inflammatory reaction (TNF-α, IL-6) and bone metabolism (ALP, BGP) were compared between two groups. Results The scores of ODI (21.1 ± 1.7 vs. 22.5 ± 1.9, t=3.111) and VAS scores (1.2 ± 0.7 vs. 1.6 ± 0.8, t=2.101) in the study group were significantly lower than those in the control group (P<0.05). The TNF-α (367.67 ± 87.11 vs. 415.93 ± 72.62 ng/L, t=2.331) and IL-6 (71.47 ± 16.83 vs. 81.43 ± 17.24 mg/L, t=2.266) in the study group were significantly lower than those in the control group (P<0.05). The ALP (70.27 ± 7.96 vs. 65.77 ± 8.45 U/L, t=2.123) and BGP (10.29 ± 2.37 vs. 9.01 ± 2.23 g/L, t=2.127) in the study group weresignidicantly higher than those in the control group (P<0.05). Conclusions The Taohong-Siwu decoction could relieve the pain, improve the function of daily life, relieve the inflammatory reaction and increase the level of ALP and BGP in the elderly patients with osteoporotic vertebral compression fractures.