Clinical study of dexamethasone acupoint Injection combined with conventional therapy for sudden deafness / 国际中医中药杂志

ABSTRACT

Objective To evaluate the efficacy of dexamethasone acupoint injection combined with conventional therapy for the paitents with sudden deafness. Methods A total of 72 patients with sudden deafness who met the inclusion criteria were randomly divided into 2 groups with 36 in each group. On the basis of conventional therapy, the observation group injected dexamethasone at acupoints; control group intravenous drip combined with oral dexamethasone. The average hearing threshold and the efficacy of symptoms between the 2 groups were compared. Results After treatment, the average hearing threshold of the observation group (49.64 ± 20.10 dB vs. 70.44 ± 21.60 dB, t=4.231), and the control group (49.25 ± 20.80 dB vs. 65.64 ± 22.30 dB, t=3.225) were both significantly lower than those before treatment (P<0.05), but there was no significant difference between the two groups after treatment (P>0.05). The effective rate of tinnitus was 85.3％ (29/34) in the observation group and 73.5％ (25/34) in the control group, and there was significant difference between 2 groups (Z=-2.109, P=0.035). The effective rate of ear fullness was 92.6％ (25/27) in the observation group and 82.8％ (24/29) in the control group, and the difference between the two groups was statistically significant (Z=-2.109, P=0.035). The effective rate of dizziness in the observation group was 92.9％ (13/14), whild the control group was 69.2％ (9/13), and the difference between the two groups was statistically significant (Z=-2.136, P=0.033). After treatment, the effective rates of the patients in the observation group of ≤7 days and >7 days were 90.5％ (19/21) and 66.7％ (10/15) respectively (Z=-2.162, P=0.031), while in the control group they were 73.9％ (17/23) and 46.2％ (6/13) respectively (Z=1.991, P=0.046). Conclusions The Dexamethasone acupoint injection combined with conventional therapy can effectively improve the accompanying symptoms such as tinnitus, ear fullness and vertigo in sudden deafness.