Clinical observation and effects by the methods of Xingshen-Kaiqiao to treat diffuse axonal injury combined with western medicine normal treatment / 国际中医中药杂志

ABSTRACT

Objective In order to observe the clinical curative effect of magnesium sulfate combined with Xingshen-Kaiqiao acupuncture for the diffuse axonal injury (DAI). Methods A total of 60 patients with DAI were divided into the Xingshen-Kaiqiao group and control group according to the random number table method (30 in each). The control group was given traditional Chinese medicine wash-out on the basis of conventional therapy, saline 100 ml+25% magnesium sulfate 8 ml and slow intravenous infusion, then 5% glucose 500 ml+25% magnesium sulfate 8 ml and slow intravenous drip; during the duration of the drug, the concentration of blood magnesium was strictly monitored and the dosage was adjusted as appropriate. And the Xingshen-Kaiqiao group was given acupuncture of Xingshen-Kaiqiao on the basic treatment of the control group. All treatments lasted 4 weeks. After treatment, the expression levels of IL-1β and TNF-α, GSC score, recovery of consciousness and GOS were evaluated and compared before and after treatment. Results After treatment, the IL-1β (62.38 ± 16.92 pg/ml vs. 88.37 ± 14.71 pg/ml, t=8.554), the TNF-α (3.59 ± 1.05 pg/ml vs. 4.06 ± 1.62 pg/ml, t=5.081) of Xingshen-Kaiqiao group were significantly lower than those of the control group (P＜0.05). The GSC scores after 1st week (8.26 ± 0.76 vs. 6.83 ± 0.82, t=-5.036), 2nd week (10.61 ± 0.82 vs. 8.91 ± 0.35, t=-4.387), 3rd week (12.52 ± 1.07 vs. 10.95 ± 0.67, t=-5.212), 4th week (13.26 ± 1.08 vs. 11.58 ± 1.86, t=-5.031) of Xingshen-Kaiqiao group were significantly higher than those of the control group ( P＜0.05). After treatment, the Xingshen-Kaiqiao group awakening rate was 70.0% (21/30) and the control group was 43.3% (13/30), and the difference in awakening rate was statistically significant (χ2=4.344, P=0.037). The awakening time (7.6 ± 3.1 d vs. 11.5 ± 4.9 d, t=6.586) of Xingshen-Kaiqiao group was significantly lower than the control group (P＜0.05); the percentage of GOS was significantly higher than the control group (Z=-2.093, P=0.036). Conclusions Magnesium sulfate combined with acupuncture of Xingshen-Kaiqiao can reduce the awakening time, the death rate and showe more satisfactory clinical efficacy for the patients with DAI.