Effect of Longxuejie capsule combined with Jiuhua ointment treatment on wound after ring-like mixed hemorrhoid surgery / 国际中医中药杂志

ABSTRACT

Objective To study the effect of Longxuejie capsule combined with Jiuhua ointment treatment on wound after ring-like mixed hemorrhoid surgery.Methods A total of 107 patients with ring-like mixed hemorrhoid (RMH) were randomly divided into the control group and the treatment group.All the patients were treated with the surgery,and then the control group were treated with Mayinglong ointment,while the treatment group were treated with Longxuejie capsule combined with Jiuhua ointment.The two groups were treated for 10 days.The clinical efficacy of the two groups after treatment were compared.The VAS score,edema degree score,wound drainage score,wound area score and wound granulation tissue score of the two groups were compared before and after treatment.The serum VEGF,PDGF and bFGF of the two groups were compared before and after treatment.The adverse reactions rates of the two groups during the treatment were compared.Results The total efficacy rate of the treatment group was 92.59％ (50/54),which was significantly higher than 77.4％ (41/53) of the control group (x2=4.881,P=0.027).After treatment,the VAS (0.8 ± 0.2 vs.1.6 ± 0.3,t=13.915),edema degree score(0.3 ± 0.2 vs.0.8 ± 0.2,t=12.690),wound drainage (0.2 ± 0.2 vs.0.7 ± 0.2,t=l 3.054),area (0.4 ± 0.2 vs.0.9 ± 0.3,t=10.044) and wound granulation tissue (0.4 ± 0.2 vs.0.7 ± 0.2,t=7.427) of the treatment group were significantly lower than the control group (P＜0.01).After treatment,the serum VEGF (126.43 ± 14.68 ng/L vs.107.78 ± 12.26 ng/L,t=7.126),PDGF (59.42 ± 9.73 ng/L vs.48.27 ± 7.08 ng/L,t=6.767) and bFGF (99.86 ± 12.61 ng/L vs.83.67 ± 11.15 ng/L,t=7.031) of the treatment group were significantly higher than the control group (P＜0.01).Conclusions Longxuejie capsule combined with Jiuhua ointment can promote the recovery of wound of the patients after ring-like mixed hemorrhoid surgery.Its mechanism may be correlated with regulation of the expressions of VEGF,PDGF and bFGF,and promotion of formation of granulation tissue growth and repair.