Progress in the study on roles of cathepsin in hypertension / 中南大学学报(医学版)

ABSTRACT

Cardiovascular remodeling or dysfunction-induced abnormal cardiac output,blood volume and peripheral vascular resistance is an important pathophysiological mechanism for the occurrence and development of hypertension.Cathepsins are widely expressed in human various tissue and cells and they are involved in the pathogenesis of hypertension through activation of renin-angiotensin system,degradation of cytoplasmic matrix,proliferation of smooth muscle cell and hypertrophy of myocyte.The clinical studies have found that cathepsins can be used as a biomarker for hypertension.In recent years,the studies on the functions and mechanisms of cathepsins have provided a new sight and strategy for treatment of hypertension.