Progress of chimeric antigen receptor-modified T cell therapy for osteosarcoma / 基础医学与临床
Basic & Clinical Medicine
; (12): 1012-1015, 2018.
Article
in Zh
| WPRIM
| ID: wpr-694026
Responsible library:
WPRO
ABSTRACT
Osteosarcoma( OS) is one common type of bone malignancy. Conventional treatments improved survival dramatically. However, conventional therapies have a few effects on patients with metastatic disease. Targeting os-teosarcoma-associated antigen, chimeric antigen receptor-modified T cell( CAR-T) therapy may promote efficacy of treatment. Specific CAR-T treatments of osteosarcoma including targeting HER-2, IL-11Rα, ROR1 and GD2 have shown a certain therapeutic effect on osteosarcoma in some basic and clinical studies.
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WPRIM
Language:
Zh
Journal:
Basic & Clinical Medicine
Year:
2018
Type:
Article