The relationship between growth hormone, insulin-like growth factor-1 and immunity during sepsis / 中华急诊医学杂志

ABSTRACT

Objective To study the relationship between growth hormone,insulin-like growth factor-1 (IGF-1) and immunity during sepsis.Methods A total of 42 sepsis patients with complete data were selected to detect serum growth hormone,IGF-1,T cells in peripheral blood,and humoral immunity.Multifactor repeated measurement variance analysis was applied to compare various markers between sepsis group and the control group.Partial correlation analysis was used to analyze the relationship between growth hormone,IGF-1 and immunity.Results Serum growth hormone of patients in sepsis group was obviously higher than that in the control group (P =0.013 7,0.012 3,0.011 5),while IGF-1 was obviously lower in sepsis group compared with control group (P=0.014 4,0.013 5,0.013 2).Meanwhile,CD3+ (P =0.0095,0.0089,0.0092),CD4+ (P=0.0163,0.013,0.0158),CD8+ (P=0.010 1,0.019 3,0.015 5),NK (P=0.023 4,0.029 3,0.025 5) and CD19+ cell (P=0.011 3,0.010 2,0.010 0),IgA (P =0.019 3,0.017 8,0.015 7),IgG (P =0.047,0.006 9,0.005 9),and complement C3 (P =0.039 3,0.037 8,0.045 6) in peripheral blood of patients in sepsis group were obviously lower than those in control group.There were positive correlations between IGF-1 and CD3+,CD4+,CD8+,CD19+,NK cells,IgA,IgG,complement C3 (P=0.01 3,0.036,0.015,0.008,0.002,0.005,0.009,0.001) in sepsis patients.Conclusions There were abnormalities in serum growth hormone,IGF-1,cell-mediated immunity and humoral immunity found in sepsis patients.IGF-1 had the correlation with immune function affecting the prognosis of patients with sepsis.