Research Progress of the Relationship between Arginase Inhibitors and Diabetic Vascular Endothelial Function / 昆明医科大学学报
Journal of Kunming Medical University
;
(12): 120-123, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-694545
ABSTRACT
Endothelial dysfunction is a major risk factor for vascular complication. Nitric oxide (NO),the most important product of endothelial cells,lays a key role in regulating vasomotor as an endogenous vasodilatation factor. NO is produced by endothelial NO synthase (eNOS) on its substrate L-arginine. Arginase,which metabolizes L-arginine to urea and ornithine,competes directly with eNOS for L-arginine leading to the decrease of NO production. This paper reviews the basic role of arginase, the development of arginase inhibitors and its effects on diabetic vascular complications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Risk factors
Language:
Chinese
Journal:
Journal of Kunming Medical University
Year:
2018
Type:
Article
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