The Function of 5-HT(1A) Receptor and Pharmacotherapy / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 253-262, 2006.
Article
in Korean
| WPRIM
| ID: wpr-69460
ABSTRACT
5-HT(1A) receptor is implicated in the pathogenesis and the therapeutic mechanism of various psychiatric disorders. Especially, the mechanism of action of selective serotonin reuptake inhibitors (SSRIs) was hypothesized that 5-HT(1A) autoreceptor desensitization plays an important role in the treatment of depression and anxiety. 5-HT(1A) receptor stimulation may also mediate the neurogenesis of prefrontal cortex and hippocampus. The 5-HT(1A) agonism has an important meaning in the treatment of schizophrenia. Most atyptical antipsychotics have the property of 5-HT(2A) antagonist, and some have that of 5-HT(1A) agonist. In the various regions of brain, 5-HT(1A) and 5-HT(2A) have the functionally antagonistic properties. Recently, 5-HT(1A) receptor-related agents have been investigated in the treatment of acute ischemic stroke and Alzheimer's disease. Therefore, the further understanding about the 5-HT(1A) receptors in the brain functions will provide the development of future drugs and the advancement of psychopharmacology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Psychopharmacology
/
Schizophrenia
/
Antipsychotic Agents
/
Brain
/
Serotonin
/
Felodipine
/
Selective Serotonin Reuptake Inhibitors
/
Prefrontal Cortex
/
Autoreceptors
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2006
Type:
Article
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