Clinical analysis of 8 cases of neonatal hand-foot-mouth disease / 临床儿科杂志

ABSTRACT

Objective To study the clinical features,treatment and prognosis of neonatal hand-foot-mouth disease.Methods Neonatal hand-foot-mouth disease patients admitted from July 2014 to May 2016 were retrospectively studied.EV71,CA16 and universal enterovirus were detected from newborn swabs by RT-PCR.Results A total of 8 neonatal patients with hand-foot-mouth diseases,6 boys and 2 girls were diagnosed at an age ranged from 7-26 days.Of them,7 patients had exposure history.Clinical manifestations including rash (8 cases),fever (6 cases),irritability (4 cases) and vomiting (1 case),nobody suffered convulsions.The results of RT-PCR showed pathogen enterovirus not-EV71 and not-CA16.There were 5 cases of pulmonary infection treated with antibiotic therapy.All of the 8 cases had a good prognosis.Conclusions Most of the handfoot-mouth diseases had exposure history without specific clinical manifestations.They had not-EV71 and not-CA16 intestinal virus infection,some patients had pulmonary infection.Therefore,neonatal hand-foot-mouth diseases need more clinical attention.