The Clinical Effect of Administration of Magnesium Sulfate in Cardiac Surgery / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 366-375, 2006.
Article
in Korean
| WPRIM
| ID: wpr-69472
ABSTRACT
BACKGROUND:
Hypomagnesemia is a common complication after cardiac surgery with cardiopulmonary bypass. The purpose of this study was to assess the clinical beneficial effect of administration of magnesium sulfate in cardiac surgery. MATERIAL ANDMETHOD:
Thirty five patients scheduled for elective cardiac surgery were randomly assigned to magnesium group (n=20) which received magnesium sulfate in priming solution (1 g) and cardioplegic solution (1 g) or control group (n=15) which did not receive it. Arterial blood samples were drawn for measuring Mg++ and electrolytes contents, blood gas analysis, CBC, total protein, albumin, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase(LDH), troponin-I (TNI), prothrombin time (PT) and activated pratial thromboplastin time level (aPTT). Venous blood samples were drawn before and after the operation for measuring activated clotting time level (ACT).RESULT:
Mg++ levels in magensium group were higher than those of control group at intraoperative and postoperative periods (p<0.05). dysrhythmias were lower in magnesium group (8 cases out of 17 patients, 46.4%) than in control group (10 cases out of 10, 100%, p=0.050).CONCLUSION:
These results showed that administration of low dose magnesium sulfate during cardiac surgery prevented hypomagnesemia and lowered incidence of dysrhythmia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Prothrombin Time
/
Aspartate Aminotransferases
/
Thoracic Surgery
/
Bilirubin
/
Blood Gas Analysis
/
Blood Urea Nitrogen
/
Thromboplastin
/
Cardioplegic Solutions
/
Cardiopulmonary Bypass
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2006
Type:
Article
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