Effect of intravenous infusion of lidocaine on postoperative analgesia in patients undergoing laparoscopic total hysterectomy / 临床麻醉学杂志

ABSTRACT

Objective To investigate the effect of intravenous infusion of lidocaine on postoperative analgesia in patients undergoing laparoscopic total hysterectomy.Methods Eighty patients aged 28-65 years undergoing laparoscopic total hysterectomy were randomly divided into 2 groups (n=40 each):lidocaine group (group L) and control group (group C).In group L,patients assigned to received an intravenous bolus infusion of 1.5 mg/kg of lidocaine,then followed by 2 mg·kg-1 ·h-1 until the end of operation.Group C received an equal volume of normal saline (100 ml).The patients received patient-controlled intravenous analgesia (PCIA) of snfentanil after surgery,maintaining VAS score≤3.The Ramsay sedation scores and Bruggrmann comfort scale (BCS) at 2,4,8,12,24 and 48 h after operation were recorded.The consumption of sufentanil within 24 h after operation,the dose of extra sufentanil,the number of delivered doses,the times of postoperative firstly flatus and defecation,the incidence of postoperative nausea and vomiting,and total hospital stay were also observed.Results Compared with group C,the Ramsay sedation scores and BCS was increased,the consumption of sufentanil within 24 h after operation [(34.8±5.8)μg vs (49.8±12.5)μg],the dose of extra sufentanil [(22.5 ± 2.6) μg vs (46.2 ± 3.8) μg],the number of delivered doses [(20 ± 4)times vs (48± 6) times] was significantly decreased (P ＜ 0.05),the time of postoperative firstly flatus [(17±6)h vs (27±7)h] and defecation [(26±8)h vs (47±9)h] and total hospital stay [(4.5±0.5)d vs (5.6±0.8)d] was significantly shortened (P＜0.05),and the incidence of postoperative nausea (5％ vs 20％) were significantly decreased (P＜0.05) in group L.Conclusion Intravenous infusion of lidocaine can enhance postoperative analgesia and reduce the volume of opioid analgesics,and was beneficial for peristalsis and hospital for patients undergoing laparoscopic total hysterectomy.