Effect of sufentanil combined with nalbuphine on patient-controlled intravenous analgesia after cesarean section / 临床麻醉学杂志

ABSTRACT

Objective To study the effect of sufentanil combined with nalbuphine on patient-controlled intravenous analgesia (PCIA)management after cesarean section.Methods The obj ects of study included 150 primiparas who underwent cesarean section in our hospital from January 2016 to March 2017,aged 20-35 years,weighing 54-89 kg,ASA physical status Ⅰ or Ⅱ.The primiparas were randomly divided into three groups,50 in each group.Sufentanil group (group S)sufentanil 2 μg/kg+tropisetron 10 mg;Nalbuphine group (group N)nalbuphine 2 mg/kg+tropisetron 10 mg;Sufentanil combined with nalbuphine group (group SN)sufentanil 1 μg/kg+nalbuphine 1 mg/kg+tropisetron 10 mg.The VAS scores,Ramsay scores and the incidence of respiratory depression of pain (rest,coughing)and Ramsay sedation scores were observed at 1,3,6,9,12,24,36 h after the caesarean section.Actual pressing times of PCIA were further evaluated.Adverse reactions were ob-served,such as nausea and vomiting,respiratory depression.Results There was no statistical differ-ence in VAS scores,Ramsay scores and the incidence of respiratory depression of patients at rest a-mong the three groups.However,when coughing,the VAS scores in patients of group SN were sig-nificantly lower than those of groups S and N (P<0.05).The incidence of nausea and vomiting in group N and group SN was significantly lower than that in group S (P<0.05).The actual pressing times of PCIA were significantly less in group SN than those in group S and group N (P<0.05). Conclusion Sufentanil combined with nalbuphine can achieve satisfactory analgesic effect on PCIA management after cesarean section.