Relationship between methylenetetrahydrofolate reductase gene C677T position polymorphism and intracerebral hemorrhage in southern Chinese Han population / 临床神经病学杂志

ABSTRACT

Objective To explore the relationship between methylenetetrahydrofolate reductase(MTHFR)gene C677T position polymorphism and intracerebral hemorrhage(ICH)in southern Chinese Han population.Methods The MTHFR gene polymorphism were detected in 124 ICH patients(ICH group)and 149 control subjects(normal control group)who were southern Chinese Han population by SNaPshot technique.Results Compared with normal control group,the frequencies of T allele in ICH group and nonlobar ICH subgroup were significantly higher(all P<0.05);and there was no statistical significance of frequencies of C allele in ICH group and nonlobar ICH subgroup, and frequencies of T, C allele in lobar ICH subgroup(all P>0.05).There was no statistical significance of genotype frequency in ICH group, nonlobar ICH subgroup, lobar ICH subgroup and normal control group. Unconditional Logistic regression showed MTHFR gene C677T position polymorphism had no correlation with ICH group and its subgroup(all P>0.05).After confounding factors correction, ICH and nonlobar ICH subtype were significantly associated with T alleles(OR=3.77,95%CI1.40-10.16,P=0.01;OR=4.19,95%CI1.30-13.46,P=0.02),and lobar ICH subtype had no correlation with T allele(OR=2.31,95%CI0.37-14.49,P=0.37).Conclusion MTHFR gene C677T position mutation T allele may be an important risk factor for ICH in the southern Chinese Han population.