Expression of Wnt5a and Wnt11 in lung cancer and their significance / 临床与实验病理学杂志

ABSTRACT

Purpose To detect Wnt5a and Wnt11 expression in lung cancer,to explore the relationship between their expression and the types of lung cancer,and to assess the relationships between their expression and clinicopathologic factors (such as gender,age,degree of cell differentiation,lymph node metastasis).Methods The 120 cases of lung cancer were selected as the experimental group.In addition,20 cases of normal lung tissue were selected as the control group.Immunohistochemistry EnVision method was used to detect the expression of Wnt5a and Wnt11.The results were analyzed by the statistical software.Results The positive expression rate of Wnt5a and Wnt1 1 was 36％ and 38％ in 84 cases of non-small cell lung carcinoma.While the expression rate of Wnt5a and Wnt11 were low (8.3％ and 0,respectively)in 36 cases of small cell lung carcinoma.Both expression in non-small cell lung carcinoma was significantly higher than that of small cell carcinoma.The expression rate of Wnt11 in adenocarcinoma was higher (56％,while Wnt5a was 9％),and the expression rate of Wnt5a in squamous cell carcinoma was higher (50％,while Wnt11 was 25％).However,there was no significant difference between the two groups in the sex,age,differentiation and lymph node metastasis.Conclusion Both Wnt5a and Wnt11 expression was associated with lung cancer types.The positive expression rate of Wnt5a and Wnt11 in non-small cell lung carcinoma is significantly higher than that of small cell lung carcinoma.The expression level of Wnt5a is higher in squamous cell carcinoma,while Wnt11 is higher in adenocarcinoma.Both of their expression show no significant correlation with the lung cancer clinicopathological indicators (including the gender,age,degree of differentiation and lymph node metastasis in patients).