Pulmonary extranodal NK/T-cell lymphoma nasal type:a clinicopathological analysis of 3 cases / 临床与实验病理学杂志

ABSTRACT

Purpose To improve the knowledge of the clinicopathologic features of pulmonary extranodal NK/T-cell lymphoma (ENKTL).Methods Three cases of pulmonary ENKTL were analyzed retrospectively,medical recordings,imaging manifestations,pathological features,immunophenotypes,EBER in situ hybridizations and other related literatures were reviewed.Results The group was composed of 1 man and 2 women with ages ranging from 52 to 68 years.The clinical symptoms and computed tomography (CT) manifestations were nonspecific.Histological observation showed that atypical lymphocytes in bronchi and parenchyma of the lung were invasively distributed.The neoplasms presented angiocentric and angiodestructive growth patterns with different degrees of inflammatory response and necrosis.For the immunophenotypes,all cases were positive for CD3,CD56 and cytotoxic granule (TIA-1,Perforin,GranB).The positive ratios of CD5 and CD30 were both 2/3.All 3cases showed positive in situ hybridization for Epstein-Barr virusencoded small RNA (EBER).Conclusion Pulmonary extranodal NK/T-cell lymphoma is very rare with poor prognosis and difficult to diagnose.The immunohistochemical staining and molecular pathological.technology may be helpful for the diagnosis and differential diagnosis of the tumors.