Alteration of choroidal thickness in patients with obstructive sleep apnea hyponea syndrome / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

·AIM:To analyze the choroidal thickness alteration in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). ·METHODS: Seventeen patients who were diagnosed with OSAHS initially and 31 healthy individuals were enrolled. Enhanced depth imaging choriodal scans were obtained by spectral - domain optical coherence tomography. Choroidal thickness of subfovea, 2mm superior,inferior,nasal and temporal to the fovea were measured and statistically analyzed. ·RESULTS:Subfoveal choroidal thickness of the control group and the OSAHS group was 323.58 ± 58.63μ m and 316.82 ± 46. 43μ m respectively, and the difference was unsignificant(t=0.409,P=0.684). Choroidal thickness at 2mm superior to the fovea of the control group and the OSAHS group was 318.29 ± 56.89μ m and 314.29 ± 59.8μ m respectively, and the difference was unsignificant (t=0.229,P=0.820). Choroidal thickness at 2mm inferior to the fovea of the control group and the OSAHS group was 308.42± 54.95μ m and 291.65 ± 55.37μ m respectively, and the difference was not significant (t=1.009, P=0.318). Choroidal thickness at 2mm temporal to the fovea of the control group and the OSAHS group was 308. 23 ± 54.62μ m and 302. 76 ± 46. 97μ m respectively, and the difference was not significant (t = 0. 347, P = 0. 730). Choroidal thickness at 2mm nasal to the fovea of the control group and the OSAHS group was 266. 23 ± 58.10μ m and 277. 12 ± 63. 99μ m respectively, and the difference was not significant (t= -0.599, P= 0.552). There were no significant differences among subgroups after grading based on the severity of sleep apnea hypopnea index and blood oxygen concentration. ·CONCLUSION: Compared with healthy individuals, choroidal thickness of patients with OSAHS decreases slightly (except for the location of 2mm nasal to the fovea),but the alteration is not significant. The severity of OSAHS has no effect on the choroidal thickness for the patients first diagnosis of OSAHS.