Effect of intravitreal injection of Conbercept before PPV on complications and visual recovery in patients with PDR / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

AIM: To analyze the effect of intravitreal injection of Conbercept before pars plana vitrectomy (PPV) on complications and visual recovery in patients with proliferative diabetic retinopathy (PDR). METHODS: Totally 94 patients with PDR (monocular onset) were randomly divided into the experimental group (n=47) and the control group(n=47). All patients were treated by PPV. The experimental group was treated with intravitreal injection of conbercept at 5-7d before PPV while the control group was not given the intervention. The surgical time,surgical procedures,complications and visual recovery in the two groups were observed and statistically analyzed. RESULTS: The operating time of PPV for the experimental group was significantly shorter than that for the control group(72.33士15.71min vs 91.06士19.29min,P<0. 05). The incidence rates of intraoperative electric coagulation hemostasis, iatrogenic breaks and hemorrhage of new vessels in the experimental group (4%,2% and 6%) were significantly lower than those in the control group (19%, 15% and 26%; P<0.05). The mean Log Mar acuity BCVA and the macular thickness decreased significantly of the two groups at 3mo and 6mo after surgery (P<0.05). The improvement effect in the experimental group was better than that in the control group (P<0.05). CONCLUSION: The intravitreal injection of conbercept before PPV has a positive effect on reducing the incidence of intraoperative complications and promoting postoperative visual recovery in patients with PDR.