The study progress of common susceptibility genes of breast cancer / 中华内分泌外科杂志

ABSTRACT

Breast cancer is a common malignancy for women.Since 21st century,the incidence of breast cancer has been increasing all over the world and ranked first among all the female malignancies in the developed regions of Europe and America.With the increase of the morbidity of breast cancer,experts have paid more and more attention to the study of the susceptibility genes of breast cancer.The research of breast cancer susceptibility genes will help to understand the causes of breast cancer,find out available preventive measures,diagnose and treat patients with breast cancer in the early period.Specially,susceptibility genes also play an important role in the screening,early diagnosis and preventive treatment for those with family history of breast cancer or the carriers of the susceptibility genes mutation.The susceptibility genes of breast cancer include the high-penetrance susceptibility genes,the moderate-penetrance susceptibility genes,and the low-penetrance susceptibility genes.Nowadays,there are plenty of studies of BRCA1 and BRCA2,two of the high-penetrance susceptibility genes of breast cancer.The review summarizes the current study progress of the common susceptibility genes of breast cancer.