Application of DNA-image cytometry in diagnosis of breast cancer / 中华内分泌外科杂志

ABSTRACT

Objective To determine the value of DNA image cytometry (DNA-ICM) in diagnosis of breast cancer.Methods Totally 187 patients with breast or axillary mass admitted from Aug.2014 to Oct.2017 were included in the study.Fine-needle aspiration cytology (FNAC),DNA-ICM and liquid-based cytology (LBC) were employed.The results showed that 100 cases were breast cancer patients and 73 cases were benign patients.DNA-ICM and LBC were used to compare the sensitivity and specificity of the two methods.Results The sensitivity and specificity were 82.0％ and 100％ for DNA-ICM,and 69.0％ and 97.3％ for LBC.The sensitivity of DNA-ICM was significantly higher than that of LBC (P=0.033).In breast tissue,the sensitivity and specificity of DNA-ICM were 83.3％ and 100％,and they were 64.8％ and 97.5％ for LBC.The difference of sensitivity was statistically significant (P=0.028).In axillary tissue,the sensitivity and specificity of DNA-ICM were 80.4％ and 100％,and they were 73.9％ and 97.0％ for LBC.The difference was not statistically significant (P=0.456).The sensitivity of joint detection was 93.5％,significantly higher than that of LBC alone (P=0.024).The effect of joint detection was better than that of LBC.Conclusion DNA-ICM method is of great value in the diagnosis of breast cancer,which can be combined with LBC in diagnosis of breast cancer.