Risk factors between mammary atypical hyperplasia and breast cancer / 中华内分泌外科杂志

ABSTRACT

Objective To find out the correlation between mammary atypical hyperplasia and breast cancer.To pinpoint the pivotal factors in the development of atypical hyperplasia to breast cancer.To provide clinical and genic clues for early diagnosis and prevention of breast cancer combined with somatic mutation in mitochondria DNA.Methods 111 patients with mammary atypical hyperplasia and 156 patients with primary breast cancer were enrolled respectively from Jan.2013 to Oct.2014.Logistic regression analysis using SPSS 19.0 was performed to study the factors in the development of mammary atypical hyperplasia to breast cancer.Results Univariate analysis results showed a high correlation of breast cancer with age,menarche age,menopause age and times of abortion.Multivariate analysis results suggested that age,menopause age and abortion times were high risk factors of breast cancer.Conclusion Age,menarche age,menopause age and abortion times are significantly correlated with breast cancer and may be play key roles in development of mammary atypical hyperplasia to breast cancer.