The mutation site and the targeted therapy of RET proto-oncogene in medullary thyroid carcinoma / 中华内分泌外科杂志
Chinese Journal of Endocrine Surgery
;
(6): 426-429, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-695597
ABSTRACT
Medullary thyroid carcinoma (MTC) is an endocrine tumor originating from the parafollicular cells of the thyroid gland.The mutation of RET gene has been considered as the molecular basis of MTC.Different types of MTC have different RET mutation sites,and the corresponding clinical manifestations and prognosis are also very different.RET gene detection is helpful for individual accurate gene diagnosis,molecular risk assessment,individual analysis and early prevention management.Nowadays,targeted therapy for RET gene mutations in MTC has developed rapidly.Some of those drugs,which have been approved for clinical application,bring new hope for advanced MTC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Endocrine Surgery
Year:
2018
Type:
Article
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