Analysis of liver function, serum lipid and blood routine in patients with differentiated thyroid cancer before radioactive iodine treatment / 上海交通大学学报（医学版）

ABSTRACT

Objective·To investigate the effect of temporary hypothyroidism state to liver function, serum lipid and blood routine in patients with differentiated thyroid cancer (DTC) prepared for radioactive iodine treatment. Methods?·?A total of 182 patients with DTC undergoing radical operation of thyroid cancer and radioactive iodine treatment were collected. All these patients were divided into 3 groups by age 26 in young group (<30 years), 112 in middle-aged group (30-54 years) and 44 in elderly group (?≥?55 years). Indicators of liver function, blood lipids and blood routine were compared before and after operation, among groups as well. Results?·?Patients under hypothyroidism state had significantly elevations in ALT, AST, LDH and serum bile acid, but a notable decrease of serum bilirubin (all P<0.05). Meanwhile they had remarkable elevations in triglyceride, cholesterol, LDL and HDL (all P<0.05). In the young group before thyroid hypothyroidism treatment, the elevation of ALT, AST, LDH and serum bile acid were more significant than those of the middle-aged and elderly patients (all P<0.05). Conclusion?·?The temporary hypothyroidism state of differentiated thyroid cancer patients could elevate liver enzymes as well as dyslipidemia.