Research progress in mechanical alteration-activated chondrocytes-mediated post-traumatic osteoarthritis / 复旦学报（医学版）

ABSTRACT

Post-traumatic osteoarthritis (PTOA) has been drawing great attention clinically because of its tight connections with sports medicine and complicated pathogenesis as well as difficulties to heal.Chondrocyte is the only cell type in articular cartilage,and it plays an important role in the pathogenesis and progression of PTOA.Recent years,researchers mostly focus on the mechanisms,signaling and potential targets to treat osteoarthritis.Combined effects of biomechanics and the imbalance between pro-inflammation and anti-inflammation induce the PTOA eventually.This review would make a summary of the pathogenesis based on the research progress of mechanical alterationactivated chondrocytes-mediated PTOA.