Advance in the mechanism of protective effects of SGLT2 inhibitor on diabetic kidney disease / 复旦学报(医学版)
Fudan University Journal of Medical Sciences
;
(6): 250-255, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-695793
ABSTRACT
Diabetic kidney disease DKD) is one of the major causes for end-stage renal disease (ESRD),which has been the focus of both clinical and basic research.Sodium-glucose cotransport 2 (SGLT2) inhibitors are a new type of anti-diabetic drugs,which also showed reno-proteetive effects.The potential mechanisms include decreasing plasma glucose,improving glomerular hyperfiltration,reducing oxidative stress,alleviating tubulointerstitial injury,suppressing inflammation and fibrosis,decreasing the level of uric acid,and etc.This review focuses on the advance in the mechanism of protective effects of SGLT2 inhibitor on DKD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Fudan University Journal of Medical Sciences
Year:
2018
Type:
Article
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