The Clinical Study of Tongdu Tiaoshen Needling Combined with Cognitive Therapy for Post-stroke Depression Patients / 世界科学技术-中医药现代化

ABSTRACT

Objective:To observe the clinical efficacy of Tongdu Tiaoshen needling combined with cognitive therapy treating post-stroke depression.Method:Sixty patients with post-stroke depression were randomized into observation group and control group,30 cases in each group,using different methods to the two groups of patients based on basic treatment of cerebrovascular disease for 4 weeks.The observation group was intervened by Tongdu Tiaoshen needling combined with cognitive therapy,while the control group was by oral treatment of Paroxetine Hydrochloride Tablets.Cinical effects and side effects were evaluated with Hamilton Depression Scale (HAMD) and Assessment of daily living ability (Barthel index) and National Institute of and Treatment Emergent Side Effect Scale (TESS),and serum levels of 5-HT were measured before and after intervention.Result:The two groups after treatment compared with before treatment,HAMD scores were significantly lower (P＜0.05),Barthel index was increased (P＜0.05),the observation group was significantly better than the western medicine group,with significant differences between the two groups (P＜0.05),The serum 5-HT levels in two groups were significantly higher than those before treatment(P＜0.05),and the increase of 5-HT levels in the two groups was not statistically significant (P＞0.05).The total effective rate was 93.3％ in the treatment group versus 86.7％ in the control group,and the difference was statistically significant (P＜0.05).The adverse reactions in observation group was lower than that in western medicine group,the difference was statistically significant (P＜0.05).Conclusion:Tongdu Tiaoshen needling combined with cognitive therapy intervention for post-stroke depression is an effective approach to improve the depression of patients with PSD,and has good repeatability of clinical operation with low side effects.Its therapeutic mechanism may be related to increase serum 5-HT level.