Clinical Research of Yang-warming Therapy Deep Remission on Inflammatory Bowel Disease / 世界科学技术-中医药现代化

ABSTRACT

This study was aimed to observe yang-warming therapy in the overall treatment and deep remission of inflammatory bowel disease (IBD).According to the randomized controlled method,86 IBD cases were divided into the control group and the treatment group,with 43 cases in each group.Salad oxazine zyban was given as conventional treatment.In the treatment group,traditional Chinese medicine (TCM) yang-warming compound treatment was added.After 12-week treatment,observations were made on mucosal changes by colonoscopy and TCM syndrome integral in order to compare the therapeutic effects of both groups.Detections were made on intestinal flora,serum biochemical indexes (WBC,ESR,CRP,STP),and inflammation related factors (NO,TNF-α,IL-17,IL-23).The results showed that the total effective rate of the treatment group was higher than that of the control group (P ＜ 0.05).The number of escherichia coli and enterococcus in patient's intestinal tract decreased significantly;the number of bifidobacterium and lactobacillus significantly increased (P ＜ 0.05).The patient's serum WBC,CRP and ESR significantly decreased;ALB increased significantly.The effect of the treatment group was better than that of the control group (P ＜ 0.05).The patient's serum IL-17 and IL-23 content in the treatment group was significantly lower than those of the control group (P ＜ 0.05).It was concluded that yangwarming therapy has the identified effect for IBD treatment.In addition to improve patient's clinical symptoms,reduce TCM syndrome integral,it also improves the mucosal healing,affects the biochemical indexes of serum and related inflammation factors in order to have a deep remission effect of IBD.