Analysis of Serum Lp(a) Levels in Patients with Different Genotypes of HCV Infection / 现代检验医学杂志

ABSTRACT

Objective To investigate whether serum Lp(a) level was related to the different genotypes of hepatitis C virus.Methods The serum and corresponding clinical data of 105 patients (male59,female46;average age43.4± 19.8) infected HCV and 30 healthy controls in the Second Affiliated Hospital of Xi'an Jiaotong University from June 2016 to June 2017 were collected.HCV genotypes was detected by PCR-reverse point hybridization,all Lp(a) levels of serum were detected by using automatic biochemical analyzer AU5800 of Beckman.The comparison of the mean of the two samples was applied with t-test,analysis of variance was applied to compare among samples.Results There were 5 genotypes found in 105 patients,including 31 patients with genotype 1b of HCV infection,30 patients with genotype 2a infection,19 patients with genotype 3a infection,12 patients with genotype 3b infection,13 patients with genotype 6a infection.The serum levels of Lp(a) in patients infected with HCV (10.87±6.21 mg/L) were significantly lower than that of healthy controls (21.51± 12.99 mg/L),the difference was statistically significant (t =6.281,P＜0.000 1),meanwhile,the level of each genotype (3 b,6a,2a,3a and 1b was 12.51±6.11,9.75±5.73,12.28±7.63,9.22±4.47 和 10.37±5.75 mg/L,respectively) was lower than that of healthy controls,respectively (t =4.355,3.356,3.965,2.288 and 3.119,all P＜ 0.05),and the difference among genotypes was no statistically significant (F=1.091,P=0.365 4).Conclusion Compared with healthy controls,HCV could reduce the expression of serum Lp(a),but the serum Lp(a) levels were not associated with the genotypes of HCV.