Changes and Clinical Significance of Four Parameters of NLR,LMR,RDW and PLR in Patients with Benign and Malignant Ovarian Tumors / 现代检验医学杂志

ABSTRACT

Objective To explore the changes of preoperative blood parameters of ovarian cancer patients.Methods The pop ulation that we studied consisted of 29 patients with ovarian cancer and 30 cases of ovarian benign tumors controls,calculated neutrophils and lymphocytes ratio (NLR),lymphocytes and monocytes ratio (LMR),red blood cell distribution width (RDW),platelet and lymphocyte ratio (PLR) and CA-125 levels.According to the clinical stage of ovarian cancer patients,the differences of NLR,LMR,RDW,PLR and CA 125 were analyzed in different stages.The above parameters were used to draw the ROC curve for ovarian cancer.Results The average NLR,LMR,RDW,PLR and CA 125 value in experimental and controlled were 2.49±1.04 vs 1.46±0.45,4.48±1.56 vs 6.67±1.87,175.35±62.86 vs 127.11±41.99,(12.98± 0.98)％ vs (12.48±0.76)％ and (355.9±369.73)U/ml vs (12.87±6.91)U/ml respectively.The differences were statistically significant (t =4.979.4.879.3.477,2.188,5.082,all P＜0.05).(Ⅰ + Ⅱ) stage and (Ⅲ +Ⅳ) stage of ovarian cancer patients m the above mentioned parameters mean differences were statistically significant (t=3.379,2.740,3.855,2.940,3.226,all P＜0.05).The area under ROC of NLR,LMR,RDW,PLR and CA 125 value in diagnosing ovarian cancer were 0.874,0.823,0.749,0.680 and 0.905 respectively.Conclusion Some blood routine parameters can be used to identify benign and malignant ovarian tumors,and have positive significance in the clinical staging of ovarian cancer.