Protracted bacterial bronchitis and primary ciliary dyskinesia in children / 中华实用儿科临床杂志

ABSTRACT

Protracted bacterial bronchitis (PBB) and primary ciliary dyskinesia (PCD) have the same pathogenetic change of abnormal mucociliary clearance,but the initial factors are different.The former is the secondary changes caused by infections,and the latter is caused by ciliary structure and/or dysfunction.They all have chronic wet cough,so the differential diagnosis is important.Visceral transposition,recurrent otitis media,sinusitis and pseudomonas aeruginosa infection can help to identify PCD from PBB.But if the patients have recurrent PBB or no reaction to common antibiotic therapy,PCD is needed to be identified.Rational application of antibacterial drugs and whole course vaccine inoculation to prevent recurrent infections are important to both of the two diseases.