Molecular genetics of juvenile idiopathic arthritis and clinical significance / 中华实用儿科临床杂志

ABSTRACT

Juvenile idiopathic arthritis (JIA) is the most common disease in chronic rheumatic disorders,and also the major disability-causing disease in childhood.It is known that genetics may play a definite role in the pathogenesis of JIA.With the application of molecular genetics technology to JIA study,a panel of JIA-susceptible or-related genes have been revealed,among of which human leukocyte antigen loci demonstrate the highest risk correlation.JIA genetics also presents heterogenicity to some extent as with clinical heterogenicity,some of which have demonstrated certain clinical significance in evaluation of the outcome of JIA.However,more noteworthily,the current knowledge on JIA genetics may provide useful clue to future research of JIA.The review focuses on current progression and future issues in the study of JIA genetics,and thereby helps understand the pathogenesis of JIA and predict the clinical outcome.