Long-term Predictive Values of HPV Test Using Alone in Cervical Cancer Screening: A Metal Analysis / 实用妇产科杂志

ABSTRACT

Objective:To further evaluate the long-term predictive value of HPV test in cervical cancer screening.Methods:To search PubMed and Web of Science databases by computer.The studies conducted HPV-based screening program and followed up for more than 3 years were included.After data extraction,the risk of cervical intraepithelial neoplasia(CIN) grade Ⅱ or worse(CIN Ⅱ +),CIN gradeⅢ or worse(CIN Ⅲ +),and cervical cancer was evaluated through the pooled cumulative incidence and odds ratio(OR) values among women with different baseline test results.Results:Finally,26 cohort studies were included.Compared to cytology negative,negative for HPV test was associated with significantly lower incidence of cervical diseases within 3 years (CIN Ⅱ +:OR =0.500,P ＜ 0.001;CIN Ⅲ+:OR =0.377,P ＜ 0.001;cervical cancer:OR =0.546,P ＜ 0.001).The 5-year pooled cumulative incidence of CIN Ⅱ +,CIN Ⅲ + and cervical cancer in HPV negative women was lower than 3-year detection rates in cytology negative women(CIN Ⅱ +:0.47％ vs 0.60％;CINⅢ +:0.15％ vs 0.20％;cervical cancer:0.016％ vs 0.020％),while the OR values had no significant difference.Conclusions:We recommend that HPV test using alone can be considered as an alternative strategy for cervical cancer screening with five-year screening interval.