Your browser doesn't support javascript.
loading
Long-term Predictive Values of HPV Test Using Alone in Cervical Cancer Screening: A Metal Analysis / 实用妇产科杂志
Article in Zh | WPRIM | ID: wpr-696703
Responsible library: WPRO
ABSTRACT

Objective:

To further evaluate the long-term predictive value of HPV test in cervical cancer screening.

Methods:

To search PubMed and Web of Science databases by computer.The studies conducted HPV-based screening program and followed up for more than 3 years were included.After data extraction,the risk of cervical intraepithelial neoplasia(CIN) grade Ⅱ or worse(CIN Ⅱ +),CIN gradeⅢ or worse(CIN Ⅲ +),and cervical cancer was evaluated through the pooled cumulative incidence and odds ratio(OR) values among women with different baseline test results.

Results:

Finally,26 cohort studies were included.Compared to cytology negative,negative for HPV test was associated with significantly lower incidence of cervical diseases within 3 years (CIN Ⅱ +OR =0.500,P < 0.001;CIN Ⅲ+OR =0.377,P < 0.001;cervical cancerOR =0.546,P < 0.001).The 5-year pooled cumulative incidence of CIN Ⅱ +,CIN Ⅲ + and cervical cancer in HPV negative women was lower than 3-year detection rates in cytology negative women(CIN Ⅱ +0.47% vs 0.60%;CINⅢ +0.15% vs 0.20%;cervical cancer0.016% vs 0.020%),while the OR values had no significant difference.

Conclusions:

We recommend that HPV test using alone can be considered as an alternative strategy for cervical cancer screening with five-year screening interval.
Key words
Full text: 1 Index: WPRIM Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Screening_studies Language: Zh Journal: Journal of Practical Obstetrics and Gynecology Year: 2018 Type: Article
Full text: 1 Index: WPRIM Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Screening_studies Language: Zh Journal: Journal of Practical Obstetrics and Gynecology Year: 2018 Type: Article