Correlation study between X-ray calcification and expression of human epidermal growth factor receptor-2 in breast cancer / 实用放射学杂志

ABSTRACT

Objective To investigate the correlation between X-ray calcification and expression of human epidermal growth factor receptor-2 (HER-2) in breast cancer.Methods Totally 84 patients with breast cancer proved pathologically who underwent digital mammography examination before operation were collected,and HER-2 of surgical specimens were detected by immunohistochemical staining after operation.The correlation between X-ray calcification and HER-2 expression was analyzed.Results The positive expression rate and the negative expression rate of HER-2 were equal in X-ray calcified group.The negative expression rate of HER-2 was higher in the non calcified group (61.54 ％).There were no differences between the calcification type,calcification number and HER-2 expression (P＞0.05).The positive expression rate of HER-2 in calcification range ≥2 cm group was significantly higher than that in calcification range ＜2 cm group (P＜0.05).The positive expression rate of HER-2 in calcification distribution ≥2 quadrants was significantly higher than that in one quadrant group (P ＜0.01).The negative expression rate of HER-2 in cluster-like calcification was higher(61.11 ％) than that in other calcifications.Conclusion There is a certain correlation between X-ray calcification and HER-2 expression in breast cancer,which can provide a clinical reference for surgical approach and prognosis evaluation of breast cancer.