Comparison of different post label delay time in arterial spin labeling for grading of gliomas / 实用放射学杂志

ABSTRACT

Objective To evaluate the diagnostic value of arterial spin labeling(ASL)in gliomas grading with different post label delay(PLD)time.Methods A total 30 patients with postoperative histo-pathology confirmed gliomas were included in this study.3D ASL acquisition with PLD of 1 525 ms and 2 025 ms were analyzed retrospectively.Tumor blood flow(TBF)values,as well as the ratio between TBF and the mirror ROI CBF(M-TBF),the ratio between TBF and normal contra-lateral gray matter(G-TBF)were analyzed respectively.T test between HGG and LGG groups was performed with P<0.05 regarded as statistically significant different. Receiver operating characteristic curve(ROC curve)analyses were also conducted for all parameters to determine the sensitivity and specificity for grading.Spearman rank analysis was finally used to evaluate the correlation between these parameters and glioma grades.Results For 1 525 ms PLD,TBF,M-TBF and G-TBF were all significantly higher in HGG[(88.7 ± 22.9)mL/100 g·min, 1.66 ± 0.36,1.75 ± 0.48)]than that in LGG[(68.0 ± 11.9)mL/100 g·min,1.23 ± 0.19,1.17 ± 0.21)](all P<0.01).While for 2 025 ms, TBF,M-TBF and G-TBF also showed significantly higher in HGG[(80.9 ± 18.1)mL/100 g· min,1.68 ± 0.32,1.73 ± 0.34]than that in LGG[(58.0 ± 11.7)mL/100 g·min,1.21 ± 0.16,1.15 ± 0.17)](all P<0.001).For 1 525 ms PLD,AUC values of TBF,M-TBF and G-TBF were 0.806,0.875 and 0.921,respectively.While for 2 025 ms,AUC values of TBF,M-TBF and G-TBF were 0.866,0.949 and 0.977 respectively.TBF and M-TBF showed moderate positive correlation with tumor grade both in 1 525 ms and 2 025 PLD. While G-TBF showed strong positive correlation with tumor grade for 2 025 ms PLD comparing with 1 525 ms PLD,which was moderate positive correlation.Conclusion The normalized G-TBF in 2 025 ms PLD obtains the best diagnostic performance than other parameters, which can be used as a more accurate pre-operative imaging method in grading of gliomas.