Primary research of multi-voxel proton-magnetic resonance spectroscopy in Alzheimer's disease / 实用放射学杂志

ABSTRACT

Objective To explore the spatial distribution of abnormal brain areas and metabolic changes in Alzheimer's disease (AD),and provide a reference for early clinical diagnosis of AD.Methods Sixteen cases of AD patients and 1 6 healthy controls (HC)underwent multi-voxel 1H-MRS examination with semi-LASER sequence.The posterior cingulate gyrus section was localized as the volume of interest(VOI)level.The VOI consisted of bilateral posterior cingulate gyrus,occipital lobe cortex,lateral ventricle paratrigonal white matter and dorsal thalamus.N-acetylaspartate (NAA),creatine (Cr),choline (Cho),myo-inositol (MI)and glutamate-glutamine (Glx)concentration were measured.Differences in metabolite were compared between AD and HC groups.Relationships between metabolite and clinical mini-mental state examination(MMSE)score were analyzed.Results For metabolite index in VOI of right hemispherethe AD group displayed significantly lower NAA,NAA/Cr,NAA/MI and higher MI,MI/Cr levels in posterior cingulate gyrus,lower NAA,Glx levels in occipital lobe cortex,lower NAA and higher Cho levels in dorsal thalamus.For metabolite index in VOI of left hemispherethe AD group displayed significantly lower NAA,NAA/Cr,NAA/MI,Glx/Cr and higher MI/Cr levels in posterior cingulate gyrus,lower NAA and higher Cho/Cr levels in occipital lobe cortex,lower NAA and higher cho levels in lateral ventricle paratrigonal white matter,lower Glx and higher Cho levels in dorsal thalamus.NAA/Cr was positively correlated with Glx/Cr in left posterior cingulate gyrus in AD group.Conclusion NAA is decreased while MI is increased in posterior cingulate gyrus in AD patients.Cho is increased in both grey and white matter.Glx is decreased mainly within grey matter,involving both cortex and sub cortex structures.