The quantitative study of dynamic contrast-enhanced MRI with Exchange model in liver fibrosis / 实用放射学杂志

ABSTRACT

Objective To explore the value of dynamic contrast-enhanced MRI (DCE-MRI)with Exchange model in the quantitative evaluation of liver fibrosis.Methods Liver DCE-MRI was performed on 85 patients with chronic hepatitis confirmed by liver aspiration biopsy.Quantitative parameters,including volume transfer constant of the contrast agent (Ktrans),reverse reflux rate constant (Kep),volume fraction of EES (Ve),volume fraction of plasma (Vp),full perfusion (FP),portal venous perfusion (PVP),hepatic arterial perfusion (HAP),hepatic arterial perfusion index (HPI),mean transit time (MTT),time to peak (TTP) and blood volume (BV)were obtained by Exchange model.The parameters of each stage were compared by A N OVA analysis and LSD test was used for comparison between groups.Spearman rank correlation analysis was used to analyze the relationship between quantitative parameters and liver fibrosis stages.The diagnostic efficacy of Ktrans,Ve,HPI and MTT were analyzed by receiver operating curve (ROC).Results Ktransdecreased in all stages of liver fibrosis and Ve decreased in the late stages (S3 and S4)(P＜0.05).FP and PVP decreased in all stages and HAP increased in the late stage (P＜0.05);HPI,MTT and TTP increased in all stages,there were statistic differences between every two stages (P＜0.05).Ktrans and Ve were negatively correlated with live fibrosis staging (r=-0.837,-0.726, P＜0.05);PVP and FP were negatively correlated with live fibrosis staging (r=-0.927,-0.864,P＜0.05);HAP,HPI,MTT and TTP were positively correlated with live fibrosis staging (r=0.622,0.873,0.906,0.852,P＜0.05).Ktrans showed high sensitivity and specificity in diagnosis of ≥S2,≥S3 and S4 liver fibrosis;HPI and MTT showed high sensitivity,specificity and efficiency in diagnosis of every stage of liver fibrosis.Conclusion The quantitative study of DCE-MRI with Exchange model can be used for diagnosis and staging of liver fibrosis.